Science Portal: Bone


Featured Application Notes

AN-SC-06 – Application of Alvetex Scaffold for 3D Culture of Osteocytes to Investigate Regulation of Bone in Normal and Simulated Microgravity Environments

In this application note we describe work carried out by Jordan Spatz, a PhD student at Harvard-MIT Division of Health Sciences & Technology (HST) working with Professor Paola Divieti-Pajevic. Some of this data has been previously presented as a scientific poster at the 2012 Annual Society for Bone and Mineral Research meeting. We would like to thank Jordan and Paola for allowing us to show these data and images of their work on the 3D culture of Osteocytes.

AN-SC-01 – Formation of Mesenchymal Tissues in Alvetex Scaffold Derived From Stem Cells and Established Cell Lines

Based on an increasing body of evidence, it is generally accepted that culturing cells in three dimensional (3D) models can lead to superior cell viability, differentiation and function compared to existing conventional culture systems where cells largely grow as monolayers on two dimensional (2D) substrates. These enhanced qualities are important for the retention of the in vivo-like cell phenotype, cell differentiation potential and subsequent functionality as required for downstream applications. Here we demonstrate the application of AlvetexScaffold technology for the growth and differentiation of mesenchymal cells and the formation of differentiated tissues.

Related Protocols

PR-SC-43 – Total Protein Extraction from Cells Cultured in Alvetex Scaffold in 3D

PR-SC-45 – Extraction of RNA from Cells Cultured in Alvetex Scaffold in 3D

Ordering information

Alvetex Scaffold is currently available in the following formats. The formats relevant to bone are highlighted.

Product Catalogue code Presentation
Alvetex Scaffold 12 well plate AVP002-2 2 x 12 well plates, individually sterile blister packed
Alvetex Scaffold well insert holder and deep petri-dish AVP015-2 2 units, individually sterile blister packed
Alvetex Scaffold 6 well insert AVP004-12 12 inserts, individually sterile blister packed
Alvetex Scaffold 12 well insert AVP005-12 12 inserts, individually sterile blister packed
Alvetex Scaffold 24 well plate AVP006-2 2 x 24 well plates, individually sterile blister packed
Alvetex Scaffold 96 well plate AVP009-2 2 x 96 well plates, individually sterile blister packed

Alvetex Scaffold is sold through various scientific labware distributors around the world.

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