Science Portal: Co-Culture
Featured Application Note:
AN-SC-05 – Development of 3D Co-culture Models
A co-culture can be defined as the growth of more than one distinct cell type in a combined culture. Such in vitro models can provide a more physiologically relevant way of demonstrating in vivo-like tissue morphology and function. Co-cultures are useful for modelling and studying the interaction and signalling between different cell types. Co-cultures can be employed to monitor intercellular communication, cell migration dynamics, and stimulation and maintenance of cell function and differentiation. For example, in previous studies: rat primary hepatocytes have demonstrated enhanced functionality and maintained their viability for longer when co-cultured with 3T3 cells; the co-culture of carcinoma and intra-tumoural stromal cells simulated a breast cancer micro-environment, allowing cell-to-cell communication to be monitored for the initiation and progression of the cancer; a study carried out using endothelial and smooth muscle cells concluded that a co-culture enabled the structure of a vessel wall to be mimicked, creating an improved model of the in vivo environment.
Ordering information
Alvetex Scaffold is currently available in the following formats. The formats relevant to co-culture are highlighted.
| Product | Catalogue code | Presentation |
|---|---|---|
| Alvetex Scaffold Plate Starter Pack | AVP-KIT-1 | 1 x 12 well plate 1 x 24 well plate 1 x 96 well plate – all individually sterile blister packed |
| Alvetex Scaffold Well Insert Starter Pack | AVP-KIT-2 | 6 x 6 well inserts 6 x 12 well inserts 1 x deep petri-dish containing a well insert holder – all individually sterile blister packed |
| Alvetex Scaffold 12 well plate | AVP002-2 | 2 x 12 well plates, individually sterile blister packed |
| Alvetex Scaffold well insert holder and deep petri-dish | AVP015-2 | 2 units, individually sterile blister packed |
| Alvetex Scaffold 6 well insert | AVP004-12 | 12 inserts, individually sterile blister packed |
| Alvetex Scaffold 12 well insert | AVP005-12 | 12 inserts, individually sterile blister packed |
| Alvetex Scaffold 24 well plate | AVP006-2 | 2 x 24 well plates, individually sterile blister packed |
| Alvetex Scaffold 96 well plate | AVP009-2 | 2 x 96 well plates, individually sterile blister packed |
Alvetex Scaffold is sold through various scientific labware distributors around the world.
