Science Portal: Liver


Featured Application Note:

AN-SC-10 – Enhanced Structure and Viability of Liver Hepatocytes

Alvetex Scaffold is an ideal 3D substrate for in vitro culture, resulting 3D growth and extensive cell-cell contact for a wide variety of cell types.

Hepatocytes constitute the major metabolic cell type of the liver, and are central to in vitro assays designed to investigate the metabolism, biotransformation and toxicology of prospective pharmaceuticals. Liver cell lines and primary hepatocytes can be used to predict biological responses to xenobiotics in vitro. Cell lines typically lack true differentiated functionality required to reflect hepatocytes in vivo, and while primary hepatocytes are the most representative liver cell type, once removed from their native tissue environment their viability and functionality rapidly decline. The re-creation of 3D tissue environments in vitro holds real promise for the development of more representative cell based assays, and modern progress in the development of novel 3D cell culture platforms has been rapid. Alvetex Scaffold technology is an ideal basis for drug toxicology assay development due to its ease of use, its inert and reproducible structure, and its suitability for adaptation into common cell culture formats.

Related application note

AN-SC-11 – Toxicity assessment using HepG2 liver cell lines

Ordering information

Alvetex Scaffold is currently available in the following formats. The formats relevant to liver cell culture are highlighted.

Product Catalogue code Presentation
Alvetex Scaffold Plate Starter Pack AVP-KIT-1 1 x 12 well plate
1 x 24 well plate
1 x 96 well plate
– all individually sterile blister packed
Alvetex Scaffold Well Insert Starter Pack AVP-KIT-2 6 x 6 well inserts
6 x 12 well inserts
1 x deep petri-dish containing a well insert holder
– all individually sterile blister packed
Alvetex Scaffold 12 well plate AVP002-2 2 x 12 well plates, individually sterile blister packed
Alvetex Scaffold well insert holder and deep petri-dish AVP015-2 2 units, individually sterile blister packed
Alvetex Scaffold 6 well insert AVP004-12 12 inserts, individually sterile blister packed
Alvetex Scaffold 12 well insert AVP005-12 12 inserts, individually sterile blister packed
Alvetex Scaffold 24 well plate AVP006-2 2 x 24 well plates, individually sterile blister packed
Alvetex Scaffold 96 well plate AVP009-2 2 x 96 well plates, individually sterile blister packed

Alvetex Scaffold is sold through various scientific labware distributors around the world.

Find a distributor for your country »