In a paper recently published in the PLOS ONE (Public Library of Science) journal, researchers at the Heidelberg University Hospital, Germany, investigated the effects of anti-cancer drugs on inhibition of migration and invasion of colorectal cancer cells grown in 3D culture using Alvetex Scaffold. Their research has led them to recommend investigating pan-Bcl-2 inhibition as a promising approach for clinical trials.
Pan-Bcl-2 Inhibitor Obatoclax Delays Cell Cycle Progression and Blocks Migration of Colorectal Cancer Cells
Bruno Christian Koehler, Anna-Lena Scherr, Stephan Lorenz, Christin Elssner, Nicole Kautz, Stefan Welte, Dirk Jaeger, Toni Urbanik, Henning Schulze-Bergkamen
PLoS ONE 9(9): e106571.
Published September 05, 2014